Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: Biosynthesis, Chemistry, and Preparation01:25

Insulin: Biosynthesis, Chemistry, and Preparation

385
The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
385
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

327
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
327
Protein and Protein Structure02:15

Protein and Protein Structure

79.6K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
79.6K
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

5.0K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
5.0K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

1.2K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.2K
Protein Complex Assembly02:41

Protein Complex Assembly

10.6K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
10.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Forces Shaping Diversity of Hydrogen Peroxide Detoxification Potential in Ocean Microbial Ecosystems.

Environmental microbiology·2026
Same author

Nonmonotonic rate-dependent adhesion of hydrogels.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Rewriting Polymer Fate via Chemomechanical Coupling.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ<sub>2</sub>R/TMEM97: Chemical and Neurobiological Characterization.

Journal of natural products·2025
Same author

Asparagine Deamidation Attenuates Toxicity, Aggregation, and Microglial Responses of Alzheimer's Amyloid-β.

ACS chemical neuroscience·2025
Same author

Development of Insulin-Like Growth Factor Mimetic Materials.

Advanced biology·2025

Related Experiment Video

Updated: Jul 7, 2025

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

899

Self-Assembling Peptides with Insulin-Like Growth Factor Mimicry.

Abhishek Roy1, Joseph B Dodd-O1, Alicia S Robang2

  • 1Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102, United States.

ACS Applied Materials & Interfaces
|December 25, 2023
PubMed
Summary

This study introduces self-assembling peptide hydrogels that mimic insulin-like growth factor (IGF) signaling. These novel biomaterials offer improved targeting and stability for potential therapeutic applications in tissue engineering and drug design.

Keywords:
growth factor mimicryinsulin-like growth factorreceptor bindingself-assemblytissue engineering

More Related Videos

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.9K
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.2K

Related Experiment Videos

Last Updated: Jul 7, 2025

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

899
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.9K
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.2K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Molecular Signaling

Background:

  • Growth factor (GF) mimicry aims to replicate the functions of natural signaling molecules.
  • Current GF mimicry faces challenges in targeted delivery and receptor binding stability.
  • Self-assembling peptides (SAPs) offer a potential platform to overcome these limitations.

Purpose of the Study:

  • To develop synthetic, self-assembling growth factors (GFs) that mimic insulin-like growth factor (IGF) signaling.
  • To create biocompatible peptide hydrogels for enhanced GF mimicry applications.
  • To address challenges in targeted delivery and long-term stability of GF mimics.

Main Methods:

  • Utilized a self-assembling peptide (SAP) platform to create synthetic IGF-signaling GFs.
  • Fabricated peptide hydrogels with demonstrated biocompatibility.
  • Assessed hydrogel binding to IGF receptors, proangiogenic signaling activation, and in vitro angiogenesis.

Main Results:

  • Peptide hydrogels exhibited dose-dependent binding to target IGF receptors.
  • Activated proangiogenic signaling pathways and facilitated the formation of angiogenic microtubules in vitro.
  • Demonstrated long-term stability of infiltrated hydrogels, lasting weeks to months.

Conclusions:

  • Developed stable, self-assembling peptide hydrogels mimicking IGF signaling.
  • Enhanced targeting and prolonged stability of SAP/GF mimicry implants shown.
  • Potential for improved efficacy and safety in future GF mimic therapeutics.