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According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are scattered by the electron clouds around the sample atoms. The X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...

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Related Experiment Video

Updated: Jul 7, 2025

$High Pressure Single Crystal Diffraction at PX^2$

High Pressure Single Crystal Diffraction at PX^2

Published on: January 16, 2017

Exploring high-throughput synchrotron X-Ray powder diffraction for the structural analysis of pharmaceuticals.

M Reinle-Schmitt¹, D Šišak Jung², M Morin¹

¹Excelsus Structural Solutions (Swiss) AG, PARK INNOVAARE, 5234 Villigen, Switzerland.

International Journal of Pharmaceutics: X

|December 26, 2023

Summary

High-throughput synchrotron X-Ray Powder Diffraction (s-XRPD) offers rapid, high-quality pharmaceutical analysis. This technology makes complex synchrotron measurements more accessible and cost-effective for routine use.

Keywords:

Beamline automatisation High-throughput Polymorphism Synchrotron X-ray powder diffraction

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$Synthesis and Microdiffraction at Extreme Pressures and Temperatures$

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Last Updated: Jul 7, 2025

$High Pressure Single Crystal Diffraction at PX^2$

High Pressure Single Crystal Diffraction at PX^2

Published on: January 16, 2017

$X-ray Powder Diffraction in Conservation Science: Towards Routine Crystal Structure Determination of Corrosion Products on Heritage Art Objects$

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Published on: June 8, 2016

$Synthesis and Microdiffraction at Extreme Pressures and Temperatures$

Synthesis and Microdiffraction at Extreme Pressures and Temperatures

Published on: October 7, 2013

Area of Science:

Materials Science
Analytical Chemistry
Pharmaceutical Sciences

Background:

Synchrotron radiation provides superior properties like high brightness and coherence over conventional sources.
Historically, synchrotron facilities faced challenges in accessibility and operational complexity, limiting routine use.
Recent advancements in technology transfer and high-throughput systems are improving synchrotron accessibility.

Purpose of the Study:

To investigate the practical applications of synchrotron X-Ray Powder Diffraction (s-XRPD) in pharmaceutical analysis.
To demonstrate the potential of high-throughput s-XRPD systems in revolutionizing pharmaceutical analysis.
To assess the quality and comparability of s-XRPD data with laboratory-based XRPD.

Main Methods:

Utilized high-throughput synchrotron X-Ray Powder Diffraction (s-XRPD) systems.
Analyzed pharmaceutical active ingredients (API) and excipients.
Performed structural refinements and compared unit cell parameters with literature data.

Main Results:

High-throughput s-XRPD systems generated XRPD patterns of comparable or superior quality to laboratory XRPD in under 5 seconds.
Demonstrated the feasibility of high-throughput analysis for well-established pharmaceutical compounds.
Confirmed data quality through structural refinements aligning with existing literature.

Conclusions:

High-throughput s-XRPD has the potential to revolutionize pharmaceutical analysis by offering rapid, high-quality data.
Synchrotron data quality does not always need to be state-of-the-art to compete with lab-XRPD.
User-friendliness, reproducibility, accessibility, and cost-effectiveness are key for synchrotron instrumentation to be competitive.