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Acute Gastroenteritis Associated with Norovirus GII.8[P8], Thailand, 2023

Watchaporn Chuchaona, Sompong Vongpunsawad, Weerasak Lawtongkum

    Emerging Infectious Diseases
    |December 26, 2023
    PubMed

    Insights

    Human norovirus GII.8[P8] caused acute gastroenteritis in Thailand in June 2023. This genotype was infrequently detected in Thailand since 2018, with no evidence of recombination found in whole-genome sequences.

    Area of Science:

    • Virology
    • Infectious Diseases
    • Public Health

    Background:

    • Human norovirus is a leading cause of acute gastroenteritis outbreaks globally.
    • Norovirus GII.8[P8] is an emerging genotype that has been detected in various regions.
    • Understanding norovirus epidemiology is crucial for effective outbreak control.

    Purpose of the Study:

    • To characterize the norovirus genotype involved in a 2023 acute gastroenteritis outbreak in Phuket, Thailand.
    • To investigate the historical presence and genetic features of norovirus GII.8[P8] in Thailand.

    Main Methods:

    • Stool specimens from the outbreak were collected and analyzed for norovirus.
    • Reverse transcription-polymerase chain reaction (RT-PCR) was used to amplify norovirus RNA.
    • Whole-genome sequencing was performed on identified GII.8[P8] strains.
    • Phylogenetic analysis was conducted to determine genetic relationships.

    Main Results:

    • Human norovirus GII.8[P8] was identified as the causative agent of the acute gastroenteritis outbreak in June 2023.
    • Retrospective analysis revealed infrequent detection of GII.8[P8] in Thailand starting from 2018.
    • Ten whole-genome sequences of GII.8[P8] from Thailand showed no evidence of genotypic recombination.

    Conclusions:

    • Norovirus GII.8[P8] has been circulating in Thailand since at least 2018.
    • The genotype appears to be stable without evidence of recombination in the analyzed sequences.
    • Continued surveillance is necessary to monitor the emergence and evolution of norovirus genotypes in Thailand.
    Keywords:
    GII.8ThailandVP1enteric infectionsfood safetygastroenteritisnoroviruspolymeraseviruses

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