Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Modulating Mitochondrial Function after Arterial Injury: Past-to-Present Evidence for the Devising of Future Preventive and Therapeutic Strategies.

Journal of cardiovascular translational research·2026
Same author

Probiotic Lactobacillus reuteri KUB-AC5 provides cardioprotection via mitigating cardiac mitochondrial dysfunction in obese rats.

The Journal of endocrinology·2026
Same author

Cholecystectomy-induced gut dysbiosis and its consequences: bridging animal models and clinical outcomes in narrative review.

Translational gastroenterology and hepatology·2026
Same author

Potential roles of gut microbiome and metabolomes in interstitial lung disease: evidence across preclinical and clinical research.

Journal of applied microbiology·2026
Same author

Roles of Metabolomics in Allergic Rhinitis: From Cell to Bedside Investigations.

International journal of molecular sciences·2026
Same author

Stage-Associated Subgingival Dysbiosis Across the Periodontal Disease Spectrum in a Thai Cohort.

Journal of clinical periodontology·2026

Related Experiment Video

Updated: Jul 7, 2025

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.3K

Cyclosorus Terminans Extract Alleviates Neuroinflammation in Insulin Resistant Rats.

Thura Tun Oo1,2, Wasana Pratchayasakul1,2,3, Kenneth Chattipakorn1,2

  • 1Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Molecular Neurobiology
|December 26, 2023
PubMed
Summary

High-fat diets cause obesity and brain insulin resistance. Cyclosorus terminans extract effectively reduced obesity, insulin resistance, and neuroinflammation in obese rats.

Keywords:
Cyclosorus terminansInsulin sensitivityNecroptosisNeuroinflammationObesity

More Related Videos

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

9.7K
A Model of Chronic Nutrient Infusion in the Rat
08:18

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

12.7K

Related Experiment Videos

Last Updated: Jul 7, 2025

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.3K
Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

9.7K
A Model of Chronic Nutrient Infusion in the Rat
08:18

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

12.7K

Area of Science:

  • Neuroscience
  • Metabolic Disorders
  • Pharmacology

Background:

  • Extended high-fat diet (HFD) consumption leads to obesity, metabolic dysfunction, and brain insulin resistance, contributing to neuroinflammation.
  • While Cyclosorus terminans extract shows promise for obesity-related insulin resistance, its effects on neuroinflammation and brain insulin resistance in obesity remain largely uninvestigated.

Purpose of the Study:

  • To investigate the effects of Cyclosorus terminans extract on neuroinflammation and brain insulin resistance in a rat model of diet-induced obesity.
  • To compare the efficacy of Cyclosorus terminans extract with pioglitazone, a known insulin sensitizer.

Main Methods:

  • Male Wistar rats were fed either a normal diet (ND) or a high-fat diet (HFD) for 14 weeks.
  • HFD-fed rats were treated with vehicle, Cyclosorus terminans extract (100 or 200 mg/kg/day), or pioglitazone (20 mg/kg/day) for the final 2 weeks.
  • Metabolic and brain parameters, including insulin resistance, inflammation markers, and glial cell activity, were assessed.

Main Results:

  • HFD-induced obesity was associated with systemic and brain insulin resistance, neuroinflammation, microglial and astrocyte hyperactivity, and brain necroptosis.
  • Treatment with 200 mg/kg/day of Cyclosorus terminans extract significantly attenuated obesity, insulin resistance, brain insulin dysfunction, and neuroinflammation.
  • The effects of high-dose Cyclosorus terminans extract were comparable to those of pioglitazone.

Conclusions:

  • Cyclosorus terminans extract demonstrates significant therapeutic potential in mitigating obesity-related metabolic disturbances and neuroinflammation.
  • The extract effectively reverses HFD-induced brain insulin resistance and associated inflammatory pathways.
  • Cyclosorus terminans extract may serve as a promising agent for managing insulin resistance and neuroinflammation in obese conditions.