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Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
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The renal damage and mechanisms relevant to antitumoral drugs

Jiyu Tang1,2, Nan Yang2,3, Shujun Pan4

  • 1The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in Oncology
|December 27, 2023
PubMed

Insights

Chemotherapy drugs can cause kidney damage, affecting various kidney parts. Early detection and collaboration between oncologists and nephrologists are crucial for managing drug-induced kidney injury.

Area of Science:

  • Nephrology
  • Oncology
  • Pharmacology

Background:

  • Cancer therapies have advanced, but chemotherapy drugs can cause kidney injuries and electrolyte imbalances.
  • Chemotherapy-induced nephrotoxicity affects multiple kidney structures, including glomeruli, tubules, interstitium, and microvessels.
  • Mechanisms of drug-induced renal damage are not fully understood.

Purpose of the Study:

  • To provide a comprehensive review of kidney injury types and mechanisms caused by antitumoral drugs.
  • To discuss potential prevention and treatment strategies for drug-mediated renal damage.
  • To highlight the importance of biomarkers for early detection and management of kidney injury.

Main Methods:

  • Literature review of existing research on chemotherapy-induced nephrotoxicity.
  • Analysis of mechanisms underlying renal damage from antitumoral agents.
  • Discussion of clinical implications, including biomarker utility and interdisciplinary collaboration.

Main Results:

  • Chemotherapy drugs can induce diverse forms of kidney injury through various mechanisms.
  • Sensitive biomarkers in blood and urine aid in early detection and monitoring of kidney damage.
  • Interdisciplinary collaboration between oncologists and nephrologists is vital for optimal patient care.

Conclusions:

  • Understanding drug-induced nephrotoxicity mechanisms is essential for effective management.
  • Early detection using biomarkers and collaborative care improve outcomes for cancer patients.
  • Vigilance and proactive monitoring by both oncologists and nephrologists are critical to prevent and treat kidney damage.
Keywords:
antineoplastic drugsearly markersmechanismsnephrotoxicityrenal damage

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