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Psoriasis comorbid with atherosclerosis meets in lipid metabolism

Liuping Chen1, Huiqi Chen2,3, Sien Guo2,3

  • 1Department of Critical Care Medicine, The Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan, China.

Frontiers in Pharmacology
|December 27, 2023
PubMed

Insights

Psoriasis (PSO) and atherosclerosis (AS) are linked, with lipid metabolism disorders increasingly recognized as a key factor. This review explores their connection, risk factors, and treatments.

Area of Science:

  • Dermatology and Cardiology
  • Metabolic research

Background:

  • Psoriasis (PSO) affects 1%-3% of the population, with rising incidence.
  • PSO significantly increases cardiovascular disease risk, notably atherosclerosis (AS).
  • Emerging evidence links lipid metabolism disorders to PSO-AS comorbidity.

Purpose of the Study:

  • To review epidemiological data, clinical treatments, risk factors, and lipid metabolism in PSO-AS.
  • To highlight the role of lipid metabolism in the PSO-AS connection.

Main Methods:

  • Literature review of epidemiological studies.
  • Analysis of clinical treatment strategies.
  • Examination of risk factors and lipid profiles.

Main Results:

  • Inflammation was a traditional view, but lipid metabolism is now a key focus.
  • Disordered lipid metabolism is increasingly implicated in AS development in PSO patients.

Conclusions:

  • Lipid metabolism is crucial in understanding the link between psoriasis and atherosclerosis.
  • Further research into lipid pathways may offer novel therapeutic targets.

Keywords:
atherosclerosiscomorbidityinflammationlipid metabolismpsoriasis

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