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Exosomal circSCMH1/miR-874 ratio in serum to predict carotid and coronary plaque stability
Jiayu Wang1,2, Yixuan Liu3, Peiqing Tian1
1Department of Cardiology, The Second Hospital of Shandong University, Shandong, China.
Insights
The ratio of circular RNA SCMH1 to microRNA-874 (circSCMH1/miR-874) is linked to coronary artery disease and carotid plaque stability. Lower levels of this ratio indicate increased risk for acute coronary syndrome and high-risk plaques.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Molecular Biology
Background:
- Acute coronary syndrome (ACS) and acute myocardial infarction (AMI) are critical cardiovascular events.
- Carotid plaque stability is a key factor in stroke risk.
- Biomarkers for these conditions are actively sought.
Purpose of the Study:
- To investigate the correlation between the lg (circSCMH1/miR-874) ratio and ACS, AMI, and carotid plaque stability.
- To evaluate the diagnostic potential of lg (circSCMH1/miR-874) in these cardiovascular conditions.
Main Methods:
- A cohort of 701 patients was categorized into stable coronary artery disease (SCAD), ACS, and control groups.
- A subgroup of 225 patients with carotid ultrasound data was classified by plaque risk.
- Exosomal circSCMH1 and miR-874 levels were measured, and the lg (circSCMH1/miR-874) ratio was calculated.
Main Results:
- The lg (circSCMH1/miR-874) ratio decreased progressively in patients with ACS, SCAD, and controls.
- A significantly lower lg (circSCMH1/miR-874) ratio was observed in patients with medium-to-high risk carotid plaques compared to low-risk and control groups.
- Logistic regression and ROC curve analyses indicated that a decreased lg (circSCMH1/miR-874) ratio is associated with increased risk and has diagnostic value for ACS, AMI, and high-risk carotid plaques.
Conclusions:
- The lg (circSCMH1/miR-874) ratio is closely associated with coronary artery disease and carotid plaque stability.
- This ratio shows potential as a diagnostic biomarker for ACS, AMI, and unstable carotid plaques.
Background:
To investigate the correlation between lg (circSCMH1/miR-874) and acute coronary syndrome (ACS), acute myocardial infarction (AMI), and carotid plaque stability.
Methods:
701 patients were divided into stable coronary artery disease (SCAD), ACS, and control groups. Furthermore, 225 patients who underwent carotid ultrasound were selected from the above 701 patients and were divided into low-risk plaque, medium-to-high risk plaque, and control (without carotid plaques) groups. We collected their baseline characteristics and measured the contents of exosomal circSCMH1 and miR-874 in peripheral blood. Then lg(circSCMH1/miR-874) was calculated and statistical analysis was performed.
Results:
The lg (circSCMH1/miR-874) values of ACS, SCAD, and the control group decreased successively (P < 0.05). Compared with the low-risk plaque and control groups, the lg (circSCMH1/miR-874) value of medium-high risk plaque group decreased (P < 0.05). Multivariate logistic regression analysis showed that with the decrease of lg (circSCMH1/miR-874), the risk of ACS, AMI, and medium-high risk plaques increased. ROC curve analysis demonstrated that lg (circSCMH1/miR-874) has a higher diagnostic value for ACS, AMI and medium-high risk plaques than previously used predictive ratios.
Conclusion:
Lg (circSCMH1/miR-874) is closely associated with coronary and carotid plaque stability.
