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Updated: Jul 7, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
The pathogenic role of metabolism in Sjögren's syndrome
Serena Colafrancesco1, Edoardo Simoncelli2, Roberta Priori3
1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, and Rheumatology and Clinical Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS Humanitas Research Hospital, Rozzano, Italy. serena.colafrancesco18@gmail.com.
Abstract:
The link between immune cell function and cell metabolic reprogramming is currently known under the term "immunometabolism". Similarly to the Warburg's effect described in cancer cells, in activated immune cells an up-regulation of specific metabolic pathways has been described and seems to be pathogenic in different inflammatory conditions.Sjӧgren's syndrome (SS) is a systemic autoimmune disease that affects the exocrine glands and is characterised by a progressive loss of secretory function. Despite the increasing amount of evidence on the ability of metabolism in regulating cell behaviour in inflammatory or tumoral conditions, the field of metabolism in SS is still for the most part unexplored.The aim of this review is to summarise currently available studies evaluating cell metabolism in SS with a particular focus on the possible pathogenic role of metabolic changes in immune and non-immune cells in this condition.
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