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Updated: Jul 7, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Palladium-Catalyzed Enantioselective Directed C(sp3)-H Functionalization Using C5-Substituted 8-Aminoquinoline

Yi Huang1, Xiaoyan Lv1, Hua-Rong Tong1

  • 1State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.

Organic Letters
|December 27, 2023
PubMed
Summary

Researchers developed a new palladium-catalyzed method for enantioselective C-H functionalization. This approach enables precise control over reactions involving alkyl carboxamides and aryl halides, overcoming previous challenges in enantiocontrol.

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