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Clinical considerations on monkeypox antiviral medications: An overview
Fariba Pourkarim1,2, Taher Entezari-Maleki2,3
1Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmacology Research & Perspectives
|December 27, 2023
Summary
Monkeypox (mpox) treatment lacks FDA-approved drugs. Tecovirimat shows favorable efficacy and safety, making it a potential first-line option for mpox antiviral therapy.
Area of Science:
- Virology
- Infectious Diseases
- Dermatology
Background:
- Monkeypox (mpox) is a zoonotic viral disease causing significant morbidity and cosmetic issues.
- Effective antiviral treatments with favorable safety profiles are crucial for mpox management.
- Currently, no specific antiviral medication is FDA-approved for mpox treatment.
Purpose of the Study:
- To review clinical considerations for antiviral medications used in mpox treatment.
- To guide clinicians in selecting appropriate mpox antiviral therapies.
- To evaluate the safety and efficacy of candidate mpox drugs.
Main Methods:
- Literature review of clinical evidence on mpox antiviral medications.
- Analysis of safety and efficacy data for tecovirimat, brincidofovir, and cidofovir.
- Evaluation of side effect profiles and clinical considerations for each drug.
Main Results:
- Tecovirimat demonstrates favorable clinical efficacy and a good safety profile.
- Brincidofovir and cidofovir are considered candidate therapies but require careful safety consideration.
- Tecovirimat emerges as a promising first-line treatment option based on current evidence.
Conclusions:
- Tecovirimat is a viable first-line antiviral treatment for mpox due to its efficacy and safety.
- Further research and clinical guidance are needed for optimal mpox management.
- Careful consideration of safety profiles is essential when selecting mpox antiviral drugs.
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