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Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
Published on: October 20, 2018
26.7K
Human organ chips for regenerative pharmacology
Girija Goyal1, Chaitra Belgur1, Donald E Ingber1,2,3
1Wyss Institute for Biologically, Inspired Engineering at Harvard University, Boston, Massachusetts, USA.
Pharmacology Research & Perspectives
|December 27, 2023
Summary
Human organs-on-chips offer a novel in vitro model for drug discovery and toxicology, replacing animal testing. These microfluidic devices mimic human organ functions to improve clinical predictions.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Pharmacology
Background:
- Human organs-on-chips (organ chips) are microfluidic devices simulating organ-level functions.
- They utilize multi-cellular, multi-tissue structures and in vivo-like biomechanical cues.
- Organ chips serve as alternatives to animal models in drug discovery and toxicology.
Purpose of the Study:
- To review the state-of-the-art in human organ-chip technology.
- To highlight applications of organ chips in regenerative pharmacology.
- To discuss the potential of organ chips in drug discovery and toxicology testing.
Main Methods:
- Microfluidic device fabrication to mimic organ structures.
- Incorporation of multi-cellular and multi-tissue constructs.
- Application of biomechanical cues to simulate in vivo conditions.
Main Results:
- Organ chips successfully replicate complex human organ functions in vitro.
- These models demonstrate potential for predicting clinical efficacy and toxicity.
- Regenerative pharmacology applications are emerging.
Conclusions:
- Human organ chips represent a significant advancement over traditional animal models.
- They offer a more accurate and ethical approach to drug testing.
- Further development promises to enhance drug discovery and personalized medicine.
