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Related Experiment Video

Updated: Jul 7, 2025

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange

Published on: June 23, 2023

Reversible Postsynthetic Modification in a Metal-Organic Framework.

Prantik Mondal¹, Zachary Neuschuler¹, Dipendu Mandal¹

¹Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.

Angewandte Chemie (International Ed. in English)

|December 27, 2023

Summary

This summary is machine-generated.

This study demonstrates reversible postsynthetic modification (PSM) of metal-organic frameworks (MOFs) using furan-maleimide chemistry. This allows for repeated functionalization and de-functionalization of MOFs while maintaining their structure.

Keywords:

Click Chemistry Diels-Alder Metal-Organic Frameworks Postsynthetic Modification Reversible Covalent Modification

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Area of Science:

Materials Science
Chemistry

Background:

Post-synthetic modification (PSM) is crucial for engineering advanced porous materials like metal-organic frameworks (MOFs).
Developing reversible modification strategies is key for dynamic functionalization of MOFs.

Purpose of the Study:

To report a novel method for reversible PSM of a multivariate isoreticular MOF.
To demonstrate the utility of dynamic furan-maleimide Diels-Alder (DA) chemistry for MOF modification.

Main Methods:

Incorporation of furan groups into a MOF via "click" PSM.
Repeated cycles of modification and de-modification using maleimides through Diels-Alder (DA) chemistry.
Characterization of MOF structural integrity, crystallinity, and porosity after modification cycles.

Main Results:

Successful reversible PSM of the MOF was achieved using furan-maleimide DA chemistry.
The furan-appended MOF could undergo multiple modification and de-modification cycles.
Structural integrity, crystallinity, and porosity were preserved throughout the PSM cycles.

Conclusions:

Dynamic furan-maleimide DA chemistry enables efficient and reversible PSM of MOFs.
This method offers a robust approach for advanced porous solid engineering.
The MOF's properties remain intact after repeated functionalization and de-functionalization.