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Updated: Jul 7, 2025

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
Parameters of the mitral apparatus in patients with ischemic and nonischemic dilated cardiomyopathy
João Presume1,2, Mariana S Paiva1, Sara Guerreiro1
1Cardiology Department, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.
Insights
Functional mitral regurgitation, often secondary to heart disease, involves complex valve changes. A thorough assessment of the mitral valve and left ventricle is crucial for predicting outcomes and repair success.
Area of Science:
- Cardiology
- Cardiac Surgery
- Biomedical Engineering
Background:
- The mitral valve apparatus comprises the annulus, leaflets, chordae tendineae, and papillary muscles.
- Left ventricular disease can impair mitral valve function, leading to secondary mitral regurgitation.
- This condition arises from structural distortions of the mitral valve components.
Purpose of the Study:
- To review the normal anatomy and pathophysiology of mitral valve changes in dilated cardiomyopathies.
- To emphasize the importance of a comprehensive multiparametric assessment of the mitral valve apparatus and left ventricle.
- To highlight the prognostic value of anatomical parameters and their role in predicting mitral valve repair outcomes.
Main Methods:
- Narrative review of existing literature.
- Description of normal mitral valve anatomy.
- Pathophysiological analysis of mitral valve alterations in ischemic and non-ischemic dilated cardiomyopathies.
Main Results:
- Functional mitral regurgitation results from left ventricular dysfunction affecting mitral valve geometry.
- Various anatomical parameters of the mitral apparatus and left ventricle are critical for assessment.
- Quantitative regurgitation measures alone are insufficient for a complete evaluation.
Conclusions:
- A multiparametric assessment, including quantitative and anatomical parameters, is essential for understanding functional mitral regurgitation.
- These parameters provide prognostic information and predict the success of mitral valve repair.
- Understanding these complex interactions is vital for effective clinical management.
Abstract:
The mitral valve apparatus is a complex structure consisting of several coordinating components: the annulus, two leaflets, the chordae tendineae, and the papillary muscles. Due to the intricate interplay between the mitral valve and the left ventricle, a disease of the latter may influence the normal function of the former. As a consequence, valve insufficiency may arise despite the absence of organic valve disease. This is designated as functional or secondary mitral regurgitation, and it arises from a series of distortions to the valve components. This narrative review describes the normal anatomy and the pathophysiology behind the mitral valve changes in ischemic and non-ischemic dilated cardiomyopathies. It also explains the value of a complete multiparametric assessment of this structure. Not only must an assessment include quantitative measures of regurgitation, but also various anatomical parameters from the mitral apparatus and left ventricle, since they carry prognostic value and are predictors of mitral valve repair success and durability.
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