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Spotlight on Compounded Bioidentical Hormones.

Giusi Santangelo1,2,3, Antonio Simone Lagana4, Andrea Giannini1

  • 1Department of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, Policlinico Umberto I, Rome, Italy.

Gynecologic and Obstetric Investigation
|December 27, 2023
PubMed
Summary
This summary is machine-generated.

Compounded bioidentical hormone therapy (CBHT) offers personalized menopause treatment options. Further research is needed to fully understand CBHT

Keywords:
Bioidentical hormoneEstrogenHormone replacement therapyMenopausal symptomsPostmenopauseProgestin

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Area of Science:

  • Reproductive endocrinology and women's health.
  • Pharmacology and pharmaceutical sciences.
  • Evidence-based medicine.

Background:

  • The use of hormone replacement therapy (HRT) for menopause is controversial, partly due to the early termination of the Women's Health Initiative (WHI) study.
  • Physicians express ongoing concerns regarding HRT, driving interest in alternative treatments.
  • The demand for personalized medicine has led to increased use of compounded steroid hormone preparations.

Purpose of the Study:

  • To evaluate the clinical utility and current evidence supporting compounded bioidentical hormone therapy (CBHT).
  • To assess the potential of personalized steroid hormone preparations as alternatives to conventional HRT.
  • To determine the necessary steps for integrating CBHT into clinical practice.

Main Methods:

  • An extensive literature search was performed in June 2023 across major databases (MEDLINE, Embase, PubMed, Cochrane).
  • Studies meeting predefined inclusion and exclusion criteria were selected for analysis.
  • Data extraction and analysis were conducted, with discrepancies resolved through consensus.

Main Results:

  • The review focused on the clinical utility of compounded bioidentical hormones (CBHT).
  • Current evidence suggests that enhanced knowledge and awareness are crucial for considering CBHT.
  • The primary outcomes indicate a need for further investigation into CBHT's efficacy and safety.

Conclusions:

  • Compounded bioidentical hormone formulations may offer tailored therapeutic options for individual patients.
  • Further research and education are essential to establish the role of CBHT in clinical practice.
  • Personalized steroid hormone preparations represent a growing area in menopausal symptom management.