Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

Renal Failure: Dose Adjustments

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Trends in mortality of people on dialysis in England and Wales over the last 15 years.

QJM : monthly journal of the Association of Physicians·2026

Same author

Rate of decline in residual kidney function and cognitive impairment in incident haemodialysis patients: A prospective, longitudinal analysis of the BISTRO trial cohort.

PloS one·2026

Same author

Validation of the kidney failure risk equation and its impact on referral strategies for chronic kidney disease: protocol for a retrospective cohort study using national claims and laboratory data in Thailand.

BMJ open·2026

Same author

Health inequalities and kidney disease: assessing equity across the renal care pathway using routinely collected data.

Journal of nephrology·2026

Same author

Lower limb amputation in incident dialysis patients in England: incidence, outcomes and inter-centre variation from a national registry study.

Clinical kidney journal·2026

Same author

A comparative analysis of the starting modality of kidney replacement therapy amongst UK children and young adults and the association with all-cause mortality.

Pediatric nephrology (Berlin, Germany)·2026

Search research articles

Related Experiment Video

Updated: Jul 7, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Kidney Function Measures and Mortality: A Mendelian Randomization Study.

Ying Shan¹, Jingwen Zhang², Yueqi Lu³

¹Clinical Research Academy, Peking University Shenzhen Hospital, Peking University, Shenzhen, China.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation

|December 27, 2023

Summary

This summary is machine-generated.

Low kidney function (eGFR) is linked to cardiovascular death, but not all-cause or other mortality. Managing kidney health may reduce cardiovascular risk, but further research is needed.

Keywords:

Cystatin C Mendelian randomization UK Biobank cardiovascular mortality estimated glomerular filtration rate

More Related Videos

Transcutaneous Assessment of Renal Function in Conscious Rodents

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

Related Experiment Videos

Last Updated: Jul 7, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Transcutaneous Assessment of Renal Function in Conscious Rodents

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

Area of Science:

Nephrology
Cardiovascular Medicine
Epidemiology
Genetics

Background:

Low estimated glomerular filtration rate (eGFR) is associated with increased mortality risk.
The specific causes underlying this association remain largely uncertain.
This study investigates the causal link between reduced kidney function and mortality outcomes.

Purpose of the Study:

To assess the causal relationship between low eGFR and all-cause mortality.
To evaluate the causal association between low eGFR and cause-specific mortality, including cardiovascular, cancer, and infection-related deaths.

Main Methods:

Retrospective cohort study utilizing UK Biobank data from 436,214 participants.
Employed Mendelian randomization (MR) with genetic allele scores as instrumental variables.
Utilized Cox proportional hazards analysis for observational data and linear/nonlinear MR for causal inference.

Main Results:

Observational analysis revealed a nonlinear association between eGFR (estimated using cystatin C, eGFR_cyst) and all mortality outcomes.
MR analysis indicated a causal link between genetically predicted lower eGFR_cyst and increased cardiovascular mortality (HR, 1.43 per 10-mL/min/1.73m² decrement).
No causal associations were found between eGFR_cyst and all-cause mortality or noncardiovascular mortality (cancer, infection).

Conclusions:

Findings suggest a potential causal association between reduced kidney function and cardiovascular mortality in the general population.
No causal relationship was identified between eGFR and all-cause or noncardiovascular mortality.
Further research in diverse populations and individuals with advanced kidney failure is warranted to validate these findings.