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Related Experiment Video

Updated: Jul 7, 2025

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

Primary cardiac large B cell lymphoma.

Sumukh Arun Kumar¹, Rahul Mishra², Sarat Chandra Malempati³

¹Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA sumukharunkumar95@gmail.com.

BMJ Case Reports

|December 27, 2023

Summary

A rare case of primary cardiac large B-cell lymphoma with MYC and BCL6 rearrangements was diagnosed in a woman. The patient achieved a complete response to chemotherapy, despite rituximab discontinuation due to absent CD20 expression.

Keywords:

Chemotherapy Malignant and Benign haematology Medical management Pericardial disease

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Area of Science:

Oncology
Hematology
Cardiology

Background:

Primary cardiac lymphoma is a rare malignancy.
Early diagnosis and accurate characterization are crucial for effective treatment.

Observation:

A middle-aged female presented with symptoms suggestive of heart failure and pericardial effusion.
CT imaging revealed a localized pericardial mass.
Pericardial fluid analysis showed atypical lymphoid cells with specific immunophenotypic and cytogenetic markers.

Findings:

The patient was diagnosed with high-grade B-cell lymphoma with MYC and BCL6 rearrangements.
The disease was localized to the pericardium, classifying it as primary cardiac large B-cell lymphoma.
Treatment with dose-adjusted R-EPOCH chemotherapy led to a complete response.

Implications:

This case highlights the importance of considering lymphoma in the differential diagnosis of pericardial effusions and masses.
The findings underscore the efficacy of chemotherapy in primary cardiac lymphoma, even with challenges like absent CD20 expression.
Further research into the management of rare cardiac malignancies is warranted.