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Related Experiment Video

Updated: Jul 7, 2025

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
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Multiscale insights into postnatal aortic development.

Bruno V Rego1,2, Sae-Il Murtada1, Guangxin Li3

  • 1Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

Biomechanics and Modeling in Mechanobiology
|December 27, 2023
PubMed
Summary
This summary is machine-generated.

Postnatal vascular development is complex. This study reveals pulsatile stress drives collagen production in the aorta, crucial for cardiovascular health and congenital heart defect treatments.

Keywords:
AortaDevelopmentMaturationModeling

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Area of Science:

  • Cardiovascular biology
  • Developmental biology
  • Biomedical engineering

Background:

  • Postnatal vascular development and maturation are critical for cardiovascular function but remain poorly understood.
  • Understanding these processes can improve treatments for congenital heart defects, especially in pediatric patients.

Purpose of the Study:

  • To investigate the multiscale postnatal development of the murine thoracic aorta.
  • To explore relationships between mechanical stresses, extracellular matrix composition, and aortic wall development.

Main Methods:

  • Conducted a multiscale investigation of the postnatal murine thoracic aorta.
  • Examined allometric relations, in vivo mechanical stresses, and collagen/elastin expression.
  • Synthesized transcriptional data and quantitative histology.

Main Results:

  • Aortic collagen production strongly correlates with the ratio of systolic to diastolic circumferential stresses, highlighting the role of pulsatile stimuli.
  • Collagen turnover and elastic fiber compaction rates can be inferred from transcriptional and histological data.
  • Wall shear stresses remain consistent from birth to maturity, suggesting early-established homeostatic targets.

Conclusions:

  • Pulsatile mechanical stimuli are key regulators of collagen production during aortic development.
  • A combination of transcriptional and histological data can predict rates of extracellular matrix remodeling.
  • Early establishment and maintenance of stress targets may provide a homeostatic basis for vascular development.