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Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

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Published on: January 24, 2025

Microbubbles: Revolutionizing Biomedical Applications with Tailored Therapeutic Precision.

Mohit Kumar¹, Devesh Kumar¹, Shruti Chopra¹

¹Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, Punjab 151001, India.

Current Pharmaceutical Design

|December 28, 2023

Summary

Microbubbles are advanced drug delivery systems that use ultrasound to release therapeutic agents at specific sites. Their versatility supports diverse biomedical applications, including cancer and gene therapy.

Keywords:

Microbubble drug delivery dynamic tool.gene delivery ligands ultrasound

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Published on: January 10, 2017

Area of Science:

Biomedical Engineering
Nanotechnology
Drug Delivery Systems

Background:

Microbubble research has significantly advanced over the past decade for biological applications.
Microbubbles are dynamic tools in modern drug delivery, enabling targeted delivery of drugs or genes.
Ultrasound-triggered bursting of microbubbles facilitates site-specific delivery of bioactive materials.

Purpose of the Study:

To review microbubble compositions and physiochemical characteristics.
To explore innovative biomedical applications, focusing on molecular imaging and targeted drug/gene delivery.

Main Methods:

Microbubbles are prepared using methods such as cross-linking polymerization, emulsion solvent evaporation, atomization, and reconstitution.
Preparation involves polymer solutions, surfactant solutions, and specific gas or osmotic agents.
Methods ensure the creation of stable microbubbles for therapeutic applications.

Main Results:

Microbubble-based drug delivery utilizes gas-filled bubbles as carriers for therapeutic agents.
These carriers can be loaded with drugs, imaging agents, or genes for targeted delivery.
Successful application in guiding therapeutic payloads to specific anatomical locations.

Conclusions:

The utility of microbubbles in biomedical applications is expanding with novel formulations and methods.
Microbubble versatility allows customization for various medical needs.
Applications include cancer therapy, cardiovascular treatments, and gene therapy.