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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Jul 7, 2025

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
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Medulloblastoma with Subcutaneous Spread: A Rare Entity.

Siddharth Srinivasan1, Ajay Hegde1, Rajesh Nair1

  • 1Department of Neurosurgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Asian Journal of Neurosurgery
|December 28, 2023
PubMed
Summary

Subcutaneous seeding is a rare complication in pediatric medulloblastoma. This case highlights a rapid presentation of extraneural metastasis following tumor resection.

Keywords:
extraneural metastasismedulloblastomapediatricsubcutaneous spread

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Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Cancer Metastasis

Background:

  • Medulloblastoma is the most common malignant pediatric brain tumor.
  • Advances in histology and adjuvant therapy have improved outcomes.
  • Extraneural metastasis is a significant poor prognostic factor.

Purpose of the Study:

  • To report a rare case of rapid subcutaneous seeding in a pediatric medulloblastoma patient.
  • To emphasize the importance of recognizing rare metastatic patterns.

Main Methods:

  • Case report of a 3-year-old child.
  • Description of clinical presentation and tumor resection.
  • Documentation of rapid subcutaneous seeding post-surgery.

Main Results:

  • The patient developed widespread subcutaneous seeding one month after gross total resection.
  • This presentation is rarely encountered in the pediatric population.

Conclusions:

  • Subcutaneous seeding can occur rapidly in pediatric medulloblastoma.
  • Vigilance for rare metastatic sites is crucial for patient management and prognosis.