Related Experiment Video
Updated: Jul 7, 2026
08:58
Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test
Published on: April 30, 2019
8.9K
Rabies post-exposure prophylaxis delivery to ensure treatment efficacy and increase compliance
Deborah Nadal1,2, Katrin Bote2, Ramesh Masthi3
1Department of Humanities, Ca' Foscari University of Venice: Malcanton Marcorà, Dorsoduro 3484/D, 30123 Venice, Italy.
IJID One Health
|December 28, 2023
Summary
Post-exposure prophylaxis (PEP) is vital for preventing rabies, a lethal disease. This guide offers healthcare providers clear, visual instructions for correct PEP administration, aiming to reduce rabies deaths globally.
Area of Science:
- Public Health
- Infectious Diseases
- Vaccinology
Background:
- Rabies is a fatal viral disease once symptoms manifest.
- Despite available vaccines, high global rabies burden persists.
- Challenges remain in accessing and delivering adequate post-exposure prophylaxis (PEP).
Purpose of the Study:
- To provide healthcare professionals with updated, visual guidance on correct PEP administration.
- To improve compliance and reduce misconceptions regarding animal bite treatment and rabies risk.
Main Methods:
- Detailed description of PEP steps: wound washing, biological assessment, administration of rabies immunoglobulin/monoclonal antibodies, and WHO-recommended intradermal vaccination.
- Emphasis on clear doctor-patient communication and knowledge sharing among healthcare providers.
Main Results:
- The WHO-recommended intradermal 1-week vaccination regimen is safe and offers significant cost, dose, and time-sparing benefits.
- Effective PEP administration relies on correct biologicals application and clear communication.
Conclusions:
- This resource aims to prevent rabies-related deaths by ensuring proper PEP delivery.
- Empowering healthcare providers with accurate knowledge is key to combating rabies.
Related Concept Videos
01:14Prevention of Further Absorption of Poison
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
01:26Pharmaceutical Poisoning: Treatment Strategies
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
01:26Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
01:24Smallpox
Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
01:28Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...