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Engineered Exosome for Drug Delivery: Recent Development and Clinical Applications
Jiaqi Tian1, Zhengpu Han1,2, Dandan Song1
1Clinical Medical Research Center for Women and Children Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, People's Republic of China.
International Journal of Nanomedicine
|December 28, 2023
Summary
Engineered exosomes show promise for treating diseases by delivering therapeutic cargo. However, challenges in production, standardization, and clinical translation must be overcome for widespread use in nanomedicine.
Area of Science:
- Biotechnology and Nanomedicine
- Cell Biology and Vesicular Transport
Background:
- Exosomes are nano-sized vesicles involved in intercellular communication.
- Engineered exosomes offer therapeutic potential for various diseases, including cancer and neurological disorders.
Purpose of the Study:
- To review advances and challenges in translating engineered exosomes for clinical applications.
- To focus on drug loading strategies, production optimization, and clinical translation hurdles.
Main Methods:
- Review of current literature on exosome engineering and drug delivery.
- Analysis of different methods for loading therapeutic cargo into exosomes.
- Discussion of challenges in exosome production, standardization, and clinical application.
Main Results:
- Engineered exosomes can be modified to carry therapeutic agents for targeted delivery.
- Various drug loading methods exist, each with distinct advantages and disadvantages.
- Significant challenges remain in large-scale production, quality control, and clinical translation.
Conclusions:
- Engineered exosomes represent a promising nanomedicine platform for targeted disease treatment.
- Addressing challenges in manufacturing, stability, and standardization is crucial for clinical success.
- Further research is needed to fully realize the therapeutic potential of exosome-based drug formulations.
