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Pediatric Meningiomas: Current Insights on Pathogenesis and Management
Luis Azmitia1,2, Gerardo Taylor3, Luca Massimi1
1Department of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, Rome, Italy.
Acta Neurochirurgica. Supplement
|December 28, 2023
Summary
Pediatric meningiomas (PMs) are rare brain tumors with unique features and higher-grade variants compared to adults. Understanding PM pathogenesis and molecular aspects is crucial for effective multidisciplinary management.
Area of Science:
- Pediatric oncology
- Neuro-oncology
- Tumor biology
Background:
- Meningiomas are rare in children, comprising 0.4–4% of intracranial tumors.
- Pediatric meningiomas (PMs) exhibit distinct characteristics from adult counterparts, including tumoral cysts, intraventricular involvement, and lack of dural attachment.
- A significant difference is the high incidence (over 70%) of WHO grade II and III variants in pediatric cases.
Approach:
- This review synthesizes current knowledge on pediatric meningiomas.
- It focuses on advances in pathogenesis, molecular characteristics, and management strategies.
- The goal is to enhance understanding and guide multidisciplinary care for these challenging neoplasms.
Key Points:
- Prognosis of PMs is heavily reliant on initial surgical resection.
- Radiotherapy shows limited efficacy in improving relapse-free or overall survival for recurrent/progressive PMs.
- Current chemotherapy protocols lack specific and effective options for PM treatment.
Conclusions:
- There is a critical need for improved understanding of PMs.
- Advances in pathogenesis and molecular insights are essential.
- Optimizing multidisciplinary management is key to improving outcomes for pediatric meningioma patients.
