Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

731
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
731
Disorders of Hemostasis01:24

Disorders of Hemostasis

922
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
922
Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

1.5K
In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
1.5K
Contaminants and Errors01:16

Contaminants and Errors

94
Effective sample preparation is crucial for accurate and reliable laboratory analysis. During this process, two significant sources of error can arise: concentration bias from improper sample splitting and contamination caused by methods used to reduce particle size, such as grinding or homogenization. Identifying and minimizing these potential errors is crucial to ensuring the validity of the analysis.
Another key consideration is determining the appropriate number of samples required to...
94
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

702
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
702

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonization and Standardization Challenges in Antidouble-Stranded DNA Detection: A Comparative Performance Study.

Annals of African medicine·2026
Same author

Point-of-Care versus Central Laboratory Testing: Accuracy, Reliability, and Clinical Utility for Hematologic, Electrolyte, and Metabolic Parameters.

Annals of African medicine·2026
Same author

Renal Biomarkers of Injury as Early Predictors of COVID-19 Associated Acute Kidney Injury: A Prospective Observational Trial (BRICOAKI Study).

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2026
Same author

Photophoretic Trapping: Fundamentals, Advances, and Future Directions.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026
Same author

Harvesting the Spin-Orbit Interaction of Light to Generate Helicity-Dependent Complex Rotational Motion in Optically Trapped Mesoscopic Matter.

Nanophotonics (Berlin, Germany)·2026
Same author

Double Jeopardy!

Indian journal of clinical biochemistry : IJCB·2026
Same journal

Accuracy of emergency physicians' probability estimates for acute coronary syndrome.

Diagnosis (Berlin, Germany)·2026
Same journal

Interfering factors in the normative diagnostic approach.

Diagnosis (Berlin, Germany)·2026
Same journal

Using generative AI to support clinical reasoning coaching: a theory-informed approach.

Diagnosis (Berlin, Germany)·2026
Same journal

Learning from what went right: a Safety-II application of the SIDER protocol to a case of occult breast cancer.

Diagnosis (Berlin, Germany)·2026
Same journal

Impact of clinical reasoning and diagnostic error education for nurses.

Diagnosis (Berlin, Germany)·2026
Same journal

Progress in mast cell activation syndrome: the global consensus-2 diagnostic criteria at six years.

Diagnosis (Berlin, Germany)·2026
See all related articles

Related Experiment Video

Updated: Jul 6, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

13.8K

Pre-analytical errors in coagulation testing: a case series.

Mala Mahto1, Visesh Kumar2, Ayan Banerjee1

  • 1Department of Biochemistry, All India Institute of Medical Sciences, Patna, India.

Diagnosis (Berlin, Germany)
|December 28, 2023
PubMed
Summary
This summary is machine-generated.

Pre-analytical errors in coagulation testing, such as improper blood-to-anticoagulant ratios, can lead to inaccurate results. A disciplined approach by lab staff is crucial to prevent these errors and ensure patient safety.

Keywords:
PT/INRactivated partial thromboplastin time (aPTT)coagulation profilepreanalytical errors

More Related Videos

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

13.8K
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

775

Related Experiment Videos

Last Updated: Jul 6, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

13.8K
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

13.8K
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

775

Area of Science:

  • Clinical pathology
  • Laboratory medicine
  • Hematology

Background:

  • Pre-analytical variables significantly impact the accuracy of coagulation testing.
  • Common errors include sample hemolysis, icterus, lipemia, clotting, and incorrect blood-to-anticoagulant ratios.
  • Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are particularly susceptible to pre-analytical errors.

Observation:

  • This case series describes four instances of unexpectedly abnormal coagulation profiles due to a casual approach to testing.
  • Retrospective analysis by clinicians and lab physicians was essential to identify and rectify the errors.
  • These errors led to incorrect reporting and potential misdiagnosis.

Findings:

  • Analytical errors in coagulation parameters are often avoidable and stem from pre-analytical variables.
  • Spurious results for coagulation tests cause significant distress to both patients and healthcare providers.
  • A systematic and careful approach to sample handling is necessary to minimize these errors.

Implications:

  • Accurate coagulation testing is vital for surgical decision-making and life-saving interventions.
  • Implementing strict pre-analytical protocols can prevent stressful and potentially harmful errors.
  • Ensuring laboratory staff diligence safeguards patient care and diagnostic reliability.