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Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
Published on: June 20, 2019
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Degradable Block Copolymer Nanoparticles Synthesized by Polymerization-Induced Self-Assembly.
Shudi Zhang1, Ruoyu Li1, Zesheng An1,2
1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.
Angewandte Chemie (International Ed. in English)
|December 28, 2023
Summary
This review highlights the synthesis of degradable block copolymer nanoparticles using polymerization-induced self-assembly (PISA). It covers core-degradable, shell-degradable, and fully degradable nanoparticles for environmental sustainability.
Area of Science:
- Materials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Polymerization-induced self-assembly (PISA) is a key technique for high-concentration nanoparticle synthesis.
- Persistent synthetic polymers pose environmental risks and waste resources.
- Developing degradable polymers is crucial for sustainability.
Purpose of the Study:
- To review the advancements in synthesizing degradable block copolymer nanoparticles via PISA.
- To categorize degradable PISA nanoparticles based on their degradation sites (core, shell, or both).
Main Methods:
- Introducing degradable linkages into either the core-forming or shell-forming blocks during PISA.
- Synthesizing shell-degradable, core-degradable, and all-degradable PISA nanoparticles.
Main Results:
- Demonstrated successful synthesis of various degradable PISA nanoparticles.
- Highlighted the versatility of PISA in creating functional, degradable nanostructures.
Conclusions:
- Degradable PISA nanoparticles offer a sustainable alternative to persistent polymers.
- Future research should focus on expanding polymerization techniques and high-throughput methods for degradable PISA systems.
