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Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Published on: July 12, 2012

Signal Transduction Associated with Mn-induced Neurological Dysfunction.

Xiao-Wei Zheng^1,2, Yuan-Yuan Fang^1,2, Jun-Jie Lin^1,2

¹Toxicology Department, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China.

Biological Trace Element Research

|December 28, 2023

Summary

Excessive manganese exposure harms the brain, causing cognitive issues like memory loss. This review details how manganese disrupts key cellular pathways, leading to neurological damage.

Keywords:

Apoptosis Autophagy Manganese Mitochondrial damage Mn-induced neurological Neuroinflammation

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Area of Science:

Environmental Health
Neuroscience
Toxicology

Background:

Manganese (Mn) is an essential trace element crucial for physiological functions.
Overexposure to manganese can lead to significant neurotoxicity, particularly affecting cognitive functions.
Known cognitive impairments include learning disabilities and memory loss.

Purpose of the Study:

To review recent advancements in understanding manganese-induced neurological dysfunction.
To explore the molecular mechanisms underlying manganese neurotoxicity.
To highlight the role of various signaling pathways in manganese-related nervous system damage.

Main Methods:

Literature review of recent scientific research.
Analysis of studies investigating manganese's impact on cellular and molecular pathways.
Synthesis of findings on endoplasmic reticulum stress, apoptosis, and neuroinflammation.

Main Results:

Manganese targets multiple critical metabolic and signaling pathways in the nervous system.
Key affected pathways include endoplasmic reticulum stress, apoptosis, and neuroinflammation.
Disruption of cellular signaling and neurotransmitter metabolism contributes to neurotoxicity.

Conclusions:

Manganese neurotoxicity is a complex process involving the disruption of numerous cellular signaling pathways.
Understanding these pathways is crucial for developing strategies to mitigate manganese-induced cognitive dysfunction.
Further research into these mechanisms can inform preventative and therapeutic approaches.