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Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

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Published on: July 4, 2018

In Vitro Models for Investigating Intestinal Host-Pathogen Interactions.

Reece McCoy¹, Sophie Oldroyd¹, Woojin Yang^1,2

¹Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB3 0AS, UK.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|December 28, 2023

Summary

Infectious diseases pose a global threat. This review explores in vitro gastrointestinal models for studying pathogen infectivity and developing interventions, balancing simplicity with physiological relevance.

Keywords:

gut microbiome in vitro models organoids pathogens tissue engineering

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Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro

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Published on: March 28, 2025

Area of Science:

Microbiology
Gastroenterology
Biomedical Engineering

Background:

Rising antimicrobial resistance and novel pathogens necessitate advanced research models.
In vitro models mimicking gastrointestinal physiology are crucial for understanding host-pathogen interactions.
A balance exists between model simplicity, throughput, and physiological relevance.

Purpose of the Study:

To review intestinal structure and function.
To provide an overview of existing and emerging in vitro gastrointestinal models.
To discuss limitations and future directions in intestinal host-pathogen interrogation models.

Main Methods:

Literature review of conventional and emerging in vitro gastrointestinal models.
Discussion of engineering principles applied to advanced model development.
Analysis of model capabilities for intestinal host-pathogen studies.

Main Results:

Conventional models offer simplicity and high throughput.
Emerging models incorporate engineering for advanced monitoring.
Model selection should align with specific biological questions.

Conclusions:

Physiologically relevant in vitro models are essential for infectious disease research.
Advanced monitoring capabilities enhance host-pathogen interrogation.
Future research should focus on refining models for accurate in vivo mimicry.