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Updated: Jul 6, 2025

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
Published on: December 16, 2021
Advances in Research on Protein Arginine Methyltransferase 2: Functions and Diseases
Zhen-Qi Min1, Ming-Jun Jiang1, Xi-Lian Liu2
1Department of Vascular Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, P.O. Box: 421001, Hengyang, China.
Abstract:
Protein arginine methylation stands as a prevalent post-translational modification process, exerting vital roles in cellular signal transduction, gene expression, and cell cycle regulation. Amidst the protein arginine methyltransferase (PRMT) family, PRMT2 stands as a less explored constituent. Nonetheless, its regulatory roles in transcriptional regulation, post-transcriptional modification, methylation activity regulation, immunoregulation, and developmental regulation have garnered attention. These capabilities enable PRMT2 to exert pivotal regulatory functions in certain malignancies, metabolic disorders, inflammatory diseases, and atherosclerosis. In this review, we highlight the structure and functions of PRMT2, emphasizing its association with diseases. We also discuss PRMT2 inhibitors and explore the potential for therapeutic targeting.
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