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Glial Cells

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Related Experiment Video

Updated: Jul 6, 2025

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices

Published on: January 31, 2019

Microglial process dynamics depend on astrocyte and synaptic activity.

Ako Ikegami¹, Daisuke Kato¹, Hiroaki Wake¹

¹Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Nagoya Journal of Medical Science

|December 29, 2023

Summary

This summary is machine-generated.

Microglial process dynamics are influenced by nearby brain cell activity. Astrocytic and pre-synaptic activity distinctly alter how microglial processes survey the brain parenchyma.

Keywords:

astrocyte microglia neural activity spine synapse

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Last Updated: Jul 6, 2025

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices

Published on: January 31, 2019

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

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Published on: October 4, 2018

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Area of Science:

Neuroscience
Cell Biology
Neuroimmunology

Background:

Microglial processes constantly scan the brain parenchyma.
The influence of neighboring cell activity on microglial process dynamics remains unclear under physiological conditions.

Purpose of the Study:

To investigate whether the dynamic behavior of microglial processes is modulated by the activity of adjacent cells.
To differentiate microglial process dynamics in response to specific neural and glial activities.

Main Methods:

In vivo imaging of microglial process dynamics.
Perturbation of astrocytic activity.
Modulation of pre-synaptic activity.

Main Results:

Microglial process dynamics exhibit distinct patterns when influenced by astrocytic activity.
Pre-synaptic activity also leads to unique microglial process dynamics.
These findings reveal cell-type-specific modulation of microglial surveillance.

Conclusions:

Microglial process dynamics are not autonomous but are actively shaped by the activity of surrounding brain cells.
Astrocytic and pre-synaptic activity represent key regulators of microglial surveillance behavior.
Understanding these interactions is crucial for comprehending brain homeostasis and neuroinflammation.