Related Experiment Video

Updated: Jul 6, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

10.9K

Potential role of N6-methyladenosine modification in the development of Parkinson's disease

Jiale Zhou1, Yang Han1,2, Ruizhe Hou3

  • 1Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.

Frontiers in Cell and Developmental Biology
|December 29, 2023
PubMed

Insights

N6-methyladenosine (m6A) is a key RNA modification influencing gene expression. This review explores its role in Parkinson's disease (PD), suggesting new therapeutic avenues.

Area of Science:

  • Epigenetics
  • Neuroscience
  • Molecular Biology

Background:

  • N6-methyladenosine (m6A) is the most prevalent mRNA modification, crucial for RNA metabolism.
  • m6A regulation involves writers, erasers, and readers, impacting mRNA stability, translation, and decay.
  • m6A is abundant in the brain and linked to neurodevelopmental disorders and Parkinson's disease (PD).

Purpose of the Study:

  • To review proteins involved in m6A modification.
  • To elucidate the role of m6A in Parkinson's disease (PD).
  • To identify potential therapeutic strategies for PD based on m6A.

Main Methods:

  • Literature review of m6A modification mechanisms.
  • Analysis of studies linking m6A to neurodevelopment and PD.
  • Synthesis of current knowledge on m6A pathways in the brain.

Main Results:

  • m6A dynamically regulates multiple RNA processing steps.
  • Enrichment of m6A in the brain suggests a critical role in neuronal function.
  • Emerging evidence connects m6A dysregulation to PD pathogenesis.

Conclusions:

  • m6A modification is a significant factor in RNA biology.
  • Understanding m6A's role in PD offers novel therapeutic targets.
  • Further research into m6A could lead to effective PD prevention and treatment strategies.
Keywords:
N6-methylAdenosine (m6A)Neurological diseaseRNA methylationepigeneticsmethyltransferaseneurodevelopment

More Related Videos

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry08:45

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry

Published on: April 21, 2022

2.4K
Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

9.6K

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
553
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
273
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.0K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.4K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
7.0K