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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Related Experiment Video

Updated: Jul 6, 2025

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics
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Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics

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A Rapidly Enlarging Skin Lump.

Melroy Rasquinha1, Jason Adhikaree2

  • 1Otolaryngology, Nottingham University Hospital National Health Service (NHS) Trust, Nottingham, GBR.

Cureus
|December 29, 2023
PubMed
Summary

Skin metastasis from lung cancer is rare. This case highlights an unusual presentation of squamous cell lung carcinoma presenting as a large, fungating neck mass, emphasizing the importance of considering rare metastatic sites.

Keywords:
cutaneous malignancypainless lumpprimary lungradio-immunotherapysquamous cell lung carcinoma

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Area of Science:

  • Oncology
  • Dermatology
  • Pulmonology

Background:

  • Lung cancer is a leading cause of cancer mortality worldwide, often presenting with poor prognosis.
  • Common sites of lung cancer metastasis include the liver, brain, adrenal glands, bone, and lymph nodes.
  • Cutaneous metastasis from lung cancer is infrequent, occurring in approximately 0.7%-9% of cases.

Observation:

  • An elderly woman presented with a rapidly enlarging, fungating neck mass.
  • The neck mass was clinically concerning and required investigation.

Findings:

  • The neck lump was diagnosed as cutaneous metastasis.
  • The metastasis originated from an underlying primary squamous cell carcinoma of the lung.

Implications:

  • This case underscores the importance of considering uncommon metastatic patterns in lung cancer diagnosis.
  • Dermatologists and oncologists should be aware of the possibility of skin metastasis, even with unusual presentations like large fungating neck masses.
  • Early recognition of cutaneous metastasis can be crucial for patient management and prognosis.