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Related Experiment Video

Updated: Jul 6, 2025

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome
12:34

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Proteomic Profiles Associated With Postsurgical Progression in Nonfunctioning Pituitary Adenomas.

Tobias Hallén1,2, Gudmundur Johannsson3,4, Annika Thorsell5

  • 1Department of Neurosurgery, Sahlgrenska University Hospital, 412 65 Gothenburg, Sweden.

The Journal of Clinical Endocrinology and Metabolism
|December 29, 2023
PubMed
Summary

Researchers identified distinct proteomic profiles in nonfunctioning pituitary adenomas (NFPAs) that predict tumor progression after surgery. These protein signatures could lead to new biomarkers for better patient management.

Keywords:
nonfunctioning pituitary adenomaquantitative proteomicsreinterventiontumor progression

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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
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Area of Science:

  • Endocrinology
  • Proteomics
  • Oncology

Background:

  • Nonfunctioning pituitary adenomas (NFPAs) lack reliable biomarkers for predicting postoperative tumor progression.
  • Accurate prediction is crucial for managing residual tumors and patient outcomes.

Purpose of the Study:

  • To identify proteomic profiles associated with tumor progression in patients with NFPAs after surgery.
  • To explore potential biomarkers for predicting the need for reintervention.

Main Methods:

  • A case-controlled exploratory study involving 46 patients with residual NFPAs.
  • Comparison of proteomic profiles between patients requiring reintervention (cases) and those with stable residual tumors (controls).
  • Global quantitative proteomic analysis to identify differentially expressed proteins (DEPs).

Main Results:

  • 550 differentially expressed proteins were identified between the groups.
  • Functional enrichment analysis highlighted pathways in translation, ROBO-receptor signaling, and RNA metabolism.
  • Upregulated proteins like SNRPD1 and SRSF10 in the reintervention group are linked to tumor aggressiveness in other cancers.

Conclusions:

  • This study is the first to analyze proteomic profiles for predicting postoperative tumor progression in NFPAs.
  • Distinct proteomic profiles differentiate indolent tumors from those with aggressive postoperative behavior.
  • Proteomic profiling shows promise for predicting tumor progression and guiding treatment decisions in NFPA patients.