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Efficient and Modular Biofunctionalization of Thiophene-Based Conjugated Polymers through Embedded Latent Disulfide
Wenting Wu1, Songyan Yu1, Dylan S Forbes1
1Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Journal of the American Chemical Society
|December 29, 2023
Summary
Researchers developed a new method for creating biofunctional conjugated polymers using thiol-ene chemistry. This innovation enables the development of advanced organic semiconductors for biological applications, such as glucose sensing.
Area of Science:
- Organic electronics
- Biomaterials science
- Polymer chemistry
Background:
- Biofunctional conjugated polymers are crucial for biological applications but face challenges in biocompatible functionalization.
- Existing methods often struggle with efficiency and biocompatibility under necessary conditions.
Purpose of the Study:
- To develop a facile and biocompatible strategy for creating biofunctional conjugated polymers.
- To demonstrate the utility of these polymers in biosensing applications.
Main Methods:
- Designed a cyclic disulfide-containing dioxythiophene monomer for integration into conjugated polymers.
- Employed thiol-ene chemistry for efficient biofunctionalization.
- Utilized acid-catalyzed chain-growth polymerization to synthesize the polymers.
- Incorporated glucose oxidase enzyme for sensing applications.
Main Results:
- Successfully synthesized biofunctional conjugated polymers with embedded latent disulfide groups.
- Demonstrated the effectiveness of the thiol-ene chemistry for attaching biomolecules.
- Validated the polymer's utility in organic electrochemical transistors for selective glucose sensing.
Conclusions:
- The developed strategy offers a versatile platform for creating biofunctional organic semiconductors.
- This approach overcomes previous limitations in biocompatible functionalization of conjugated polymers.
- The work paves the way for novel biosensors and other bioelectronic devices.
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