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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Mutagenicity and Carcinogenicity01:25

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Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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The IARC Perspective on Alcohol Reduction or Cessation and Cancer Risk

Susan M Gapstur1, Véronique Bouvard1, Suzanne T Nethan1

  • 1From the International Agency for Research on Cancer, Lyon, France (S.M.G., V.B., S.T.N., B.L.-S.); the School of Public Health and Health Professions, University at Buffalo, Buffalo (J.L.F.), and the Mailman School of Public Health and the Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, Columbia University, New York (M.B.T.) - both in New York; the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (C.C.A., K.A.M.); Cancer Council Victoria and Melbourne School of Population and Global Health, University of Melbourne, Melbourne (D.R.E.), and the University of Newcastle, Callaghan, NSW (P.B.) - both in Australia; the Centre for Addiction and Mental Health, Toronto (J.R.); the School of Public Health, University of Minnesota, Minneapolis (S.B.); Eskenazi Health and Indiana University School of Medicine, Indianapolis (D.C.); the School of Medicine, Dentistry, and Nursing, University of Glasgow, Glasgow, United Kingdom (D.I.C.); American Cancer Society, Atlanta (F.I.); Chemical and Veterinary Investigation Agency Karlsruhe, Karlsruhe, Germany (D.W.L.); University of Helsinki, Helsinki (M.S.); the Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo (N.S.); and the School of Public Health, Universidade de São Paulo, São Paulo (T.T.).

The New England Journal of Medicine
|December 29, 2023
PubMed
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No abstract available in PubMed .

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