Related Experiment Video

Updated: Jul 6, 2025

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.3K

Macrophage fatty acid oxidation in atherosclerosis

Sujun Xiao1, Mingxu Qi1, Qinyi Zhou1

  • 1The Affiliated Nanhua Hospital, Department of Cardiology, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 29, 2023
PubMed

Insights

This review explores how fatty acid beta-oxidation (FAO) in macrophages impacts atherosclerosis. Targeting macrophage FAO offers a promising therapeutic strategy for cardiovascular diseases.

Area of Science:

  • Immunometabolism
  • Cardiovascular Research
  • Cellular Biology

Background:

  • Atherosclerosis, a major cause of cardiovascular disease (CVD), involves lipid buildup and inflammation in arteries.
  • Macrophages are key immune cells driving atherosclerotic inflammation.
  • Lipid metabolism, particularly fatty acid beta-oxidation (FAO), is crucial for macrophage function in this process.

Purpose of the Study:

  • To review the impact of mitochondrial FAO on macrophage phenotype and function.
  • To discuss the transcriptional regulation of FAO in macrophages.
  • To highlight therapeutic strategies targeting macrophage FAO in atherosclerosis.

Main Methods:

  • Literature review of recent findings on macrophage immunometabolism.
  • Analysis of the role of mitochondrial fatty acid beta-oxidation (FAO).
  • Examination of transcriptional regulation of FAO pathways.

Main Results:

  • Mitochondrial FAO significantly influences macrophage phenotype and inflammatory responses.
  • Transcriptional control mechanisms modulate FAO activity in macrophages.
  • Targeting macrophage FAO presents a potential therapeutic avenue for atherosclerosis.

Conclusions:

  • Macrophage FAO is a critical immunometabolic regulator in atherosclerosis.
  • Modulating macrophage FAO can impact disease progression.
  • Therapeutic strategies focused on macrophage FAO hold promise for CVD treatment.

Keywords:
AtherosclerosisFatty acid oxidationMacrophageNLRP3 inflammasomePeroxisome proliferator-activated receptors

More Related Videos

Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes11:03

Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes

Published on: September 9, 2021

3.9K
Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death08:26

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

Published on: October 31, 2017

9.3K

Related Concept Videos

Inflammation01:38

Inflammation

Overview
53.4K
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.7K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.6K
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
25.2K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
551