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Updated: Jul 6, 2025
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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
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Macrophage fatty acid oxidation in atherosclerosis
Sujun Xiao1, Mingxu Qi1, Qinyi Zhou1
1The Affiliated Nanhua Hospital, Department of Cardiology, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 29, 2023
Summary
This review explores how fatty acid beta-oxidation (FAO) in macrophages impacts atherosclerosis. Targeting macrophage FAO offers a promising therapeutic strategy for cardiovascular diseases.
Area of Science:
- Immunometabolism
- Cardiovascular Research
- Cellular Biology
Background:
- Atherosclerosis, a major cause of cardiovascular disease (CVD), involves lipid buildup and inflammation in arteries.
- Macrophages are key immune cells driving atherosclerotic inflammation.
- Lipid metabolism, particularly fatty acid beta-oxidation (FAO), is crucial for macrophage function in this process.
Purpose of the Study:
- To review the impact of mitochondrial FAO on macrophage phenotype and function.
- To discuss the transcriptional regulation of FAO in macrophages.
- To highlight therapeutic strategies targeting macrophage FAO in atherosclerosis.
Main Methods:
- Literature review of recent findings on macrophage immunometabolism.
- Analysis of the role of mitochondrial fatty acid beta-oxidation (FAO).
- Examination of transcriptional regulation of FAO pathways.
Main Results:
- Mitochondrial FAO significantly influences macrophage phenotype and inflammatory responses.
- Transcriptional control mechanisms modulate FAO activity in macrophages.
- Targeting macrophage FAO presents a potential therapeutic avenue for atherosclerosis.
Conclusions:
- Macrophage FAO is a critical immunometabolic regulator in atherosclerosis.
- Modulating macrophage FAO can impact disease progression.
- Therapeutic strategies focused on macrophage FAO hold promise for CVD treatment.
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