Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RVvictor: Virus RNA-directed molecular interactions for RNA virus infection.

Kuerbannisha Amahong1, Wei Zhang1, Yuhong Liu2

  • 1College of Pharmaceutical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou, 330110, China.

Computers in Biology and Medicine
|December 29, 2023
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of demographic factors affecting predictability of the sacro-femoral-pubic angle in healthy adolescents.

Journal of anatomy·2014
Same author

Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells.

Cancer letters·2014
Same author

[Association between -1296T/C and -915A/G polymorphisms of matrix metalloproteinase inhibitor-3 gene and atherosclerotic cerebral infarction in an ethnic Han Chinese population].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2014
Same author

A preliminary study on surgery for hepatocellular carcinoma patients with portal hypertension.

American journal of surgery·2014
Same author

[Development of CBCT technique and its application on dental age assessment].

Fa yi xue za zhi·2014
Same author

[Functional hemodynamic monitoring should be emphasized in intensive care for burn and trauma patients].

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns·2014

A new database, RVvictor, catalogs RNA virus interactions with host proteins and nucleic acids. This resource aids understanding of viral replication and disease, potentially revealing new antiviral targets.

Area of Science:

  • Virology
  • Molecular Biology
  • Bioinformatics

Background:

  • RNA viruses are significant human pathogens responsible for epidemics and pandemics.
  • Understanding virus RNA interactions with host molecules is crucial for deciphering viral replication and pathogenesis.
  • Existing data on these interactions is fragmented, hindering comprehensive analysis.

Purpose of the Study:

  • To construct a novel database, RVvictor, detailing RNA virus interactions with host proteins (INTPRO), messenger RNA (INTmRNA), and non-coding RNA (INTncRNA).
  • To provide a systematic resource for exploring molecular mechanisms of RNA virus translation and replication.
  • To facilitate the identification of potential cross-talk networks and therapeutic targets.

Main Methods:

  • Development of the RVvictor database to store and present RNA virus-directed interaction data.
Keywords:
Enrichment analysisHost proteinRNA virusRNA-Directed interactionsVirus RNA

Related Experiment Videos

  • Characterization of interactions between viral RNAs and host components.
  • Conducting comprehensive enrichment analysis of virus RNA-associated targets.

    • Main Results:

    • RVvictor uniquely characterizes virus RNA-host protein interactions.
    • The database offers the most systematic collection of RNA-directed interaction data to date.
    • Enrichment analysis revealed significant pathways related to viral infection, translation, and replication, including HIV and coronavirus disease.

    Conclusions:

    • RVvictor provides unprecedented insights into RNA virus molecular mechanisms.
    • The database may elucidate the pathogenicity of RNA virus infections through interaction networks.
    • RVvictor serves as a valuable resource for developing novel antiviral strategies and therapeutic targets.