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Related Experiment Video

Updated: Jul 6, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Structural and functional changes in the default mode network in drug-resistant epilepsy.

Jinxin Bu1, Hangxing Yin2, Nanxiao Ren1

  • 1Department of Functional Neurosurgery, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.

Epilepsy & Behavior : E&B
|December 29, 2023
PubMed
Summary

Drug-resistant epilepsy (DRE) involves altered default mode network (DMN) connectivity. Temporal lobe epilepsy (TLE) shows reduced structural and functional connections between the left hippocampus and precuneus compared to frontal lobe epilepsy (FLE).

Keywords:
Default mode networkEpilepsyFunctional connectivityProbabilistic fiber trackingVolume

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Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Brain Imaging

Background:

  • Drug-resistant epilepsy (DRE) presents significant challenges in clinical management.
  • The default mode network (DMN) plays a crucial role in intrinsic brain function and is implicated in various neurological disorders.
  • Understanding DMN alterations in DRE subtypes like temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE) is vital for targeted interventions.

Purpose of the Study:

  • To investigate brain network properties and connectivity abnormalities of the default mode network (DMN) in drug-resistant epilepsy (DRE).
  • To explore structural and functional connectivity changes within the DMN in patients with TLE and FLE using probabilistic fiber tracking and functional connectivity (FC) analysis.

Main Methods:

  • Recruited 33 DRE patients (18 TLE, 15 FLE) and 30 healthy controls (HCs).
  • Calculated DMN septal brain region volume fraction using FreeSurfer.
  • Performed FC analysis using Data Processing and Analysis for Brain Imaging (DPABI) in MATLAB and structural connectivity analysis via probabilistic fiber tracking.

Main Results:

  • Epilepsy groups exhibited lower left precuneus (PCUN) volumes compared to HCs.
  • TLE patients showed reduced FC between the left hippocampus (HIP) and PCUN/medial frontal gyrus, and between the right inferior parietal lobule (IPL) and right superior temporal gyrus, compared to FLE.
  • FLE patients demonstrated increased FCs between the right IPL and occipital lobe, and between the left superior frontal gyrus (SFG) and bilateral superior temporal gyrus, compared to HCs. TLE showed altered structural connectivity, including increased left SFG-left PCUN connectivity and reduced left HIP-left posterior cingulate gyrus/left PCUN connectivity compared to FLE.

Conclusions:

  • Both TLE and FLE patients exhibit structural and functional alterations within the DMN.
  • Reduced structural and functional connection strengths between the left HIP and PCUN were observed in TLE patients compared to FLE patients.
  • These distinct connectivity alterations may serve as potential biomarkers for differentiating TLE and FLE.