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Epigenetic alterations dictating the inflammation: A view through pancreatitis
Sreyoshi Routh1, Venkatraman Manickam1
1School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.
Life Sciences
|December 29, 2023
Summary
Pancreatitis, a severe pancreatic inflammation, involves genetic and epigenetic factors. Understanding epigenetic changes in pancreatitis inflammation is key for effective treatment and managing disease progression.
Area of Science:
- Gastroenterology and Molecular Biology
- Focuses on the molecular mechanisms underlying pancreatic diseases.
Background:
- Pancreatitis is a major global gastrointestinal disorder with significant morbidity and mortality.
- Recurrent acute pancreatitis can lead to chronic inflammation, fibrosis, and increased risk of pancreatic cancer.
Purpose of the Study:
- To review epigenetic alterations in pancreatitis pathogenesis.
- To explore the role of inflammation in pancreatitis from an epigenetic viewpoint.
Main Methods:
- Literature review focusing on genetic and epigenetic mechanisms in pancreatitis.
- Analysis of how epigenetic changes influence inflammatory pathways and disease progression.
Main Results:
- Epigenetic alterations are implicated in the development and progression of pancreatitis.
- Inflammation in pancreatitis is significantly influenced by epigenetic modifications.
Conclusions:
- Deciphering epigenetic changes offers potential for more effective pancreatitis management.
- Targeting epigenetic pathways may provide novel therapeutic strategies for pancreatitis and associated complications.
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