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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Related Experiment Video

Updated: Jul 6, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

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Updates in Osteosarcoma.

Jeffrey N Bryan1

  • 1Comparative Oncology Radiobiology and Epigenetics Laboratory, University of Missouri Columbia, Ellis Fischel Cancer Center, 900 East Campus Drive, Columbia, MO 65211, USA.

The Veterinary Clinics of North America. Small Animal Practice
|December 29, 2023
PubMed
Summary
This summary is machine-generated.

Recent advancements in canine osteosarcoma (OSA) treatment offer new hope. Innovations in genomics, imaging, and therapies like immunotherapy and radiopharmaceuticals are improving outcomes for dogs with OSA.

Keywords:
AblationCancerGenomicsOsteosarcomaPET imagingRadiopharmaceutical

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Area of Science:

  • Veterinary oncology
  • Comparative oncology
  • Canine cancer research

Background:

  • Canine osteosarcoma (OSA) treatment has remained largely unchanged for two decades.
  • Current standard care relies on amputation and platinum-based chemotherapy.
  • There is a need for improved therapeutic strategies and outcomes for canine OSA.

Purpose of the Study:

  • To review recent advancements in the clinical care of canine osteosarcoma.
  • To highlight emerging diagnostic and therapeutic innovations.
  • To discuss the potential impact of these advancements on treatment and prognosis.

Main Methods:

  • Genomic research identifying shared genetic abnormalities between canine and human OSA.
  • Multidimensional imaging techniques for staging and prognosis.
  • Review of novel therapeutic modalities including limb-sparing surgery, stereotactic body radiation therapy, ablative therapies (microwave ablation, histotripsy), immunotherapy (cell therapy, immune checkpoint inhibition), and radiopharmaceuticals.

Main Results:

  • Genomic studies reveal common genetic drivers in canine and human OSA.
  • Advanced imaging improves diagnostic accuracy and prognostic assessment.
  • Emerging therapies demonstrate promise for enhanced pain control, survival, and targeted treatment.
  • Innovations offer alternatives to traditional amputation and chemotherapy.

Conclusions:

  • Recent scientific and technological advancements are transforming canine osteosarcoma care.
  • These innovations hold significant potential to improve treatment efficacy and patient prognosis.
  • Comparative oncology research continues to drive progress in both human and canine OSA.