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Pyroptosis in microbial infectious diseases.

Cui Xiao1, Saihong Cao1,2, Yunfei Li1

  • 1Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.

Molecular Biology Reports
|December 29, 2023
PubMed
Summary

Pyroptosis, a programmed cell death, is crucial for immune regulation during microbial infections. Targeting pyroptosis offers potential therapeutic strategies for infectious diseases caused by bacteria, viruses, and fungi.

Keywords:
CaspasesGasderminsInflammasomesMicrobial infectionsPyroptosisTherapeutic strategies

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Area of Science:

  • Immunology
  • Cell Biology
  • Microbiology

Background:

  • Pyroptosis is a critical gasdermin-mediated programmed cell death pathway involved in immune responses.
  • Its roles in autoimmune diseases and cancer are well-established.
  • Emerging evidence links microbial infections to pyroptosis, influencing disease pathogenesis.

Purpose of the Study:

  • To review recent advancements in understanding pyroptosis during bacterial, viral, and fungal infections.
  • To explore the association between pyroptosis and the development of microbial infectious diseases.
  • To discuss potential therapeutic strategies targeting pyroptosis for infectious diseases.

Main Methods:

  • Literature review of recent studies on pyroptosis and microbial infections.
  • Analysis of the mechanisms linking microbial pathogens to pyroptosis induction.
  • Exploration of therapeutic interventions targeting the pyroptosis pathway.

Main Results:

  • Pyroptosis is implicated in the host immune response to a wide range of microbial pathogens.
  • Dysregulation of pyroptosis can exacerbate microbial infectious diseases.
  • Targeting pyroptosis demonstrates promise in preclinical models of infection.

Conclusions:

  • Pyroptosis is a key cellular process in the context of microbial infections.
  • Modulating pyroptosis presents a viable therapeutic avenue for treating infectious diseases.
  • Further research is warranted to translate pyroptosis-targeting therapies into clinical practice.