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Pineal peptides.

B Benson, I Ebels

    Journal of Neural Transmission. Supplementum
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified a non-melatonin antigonadotropin (PAG) in pineal extracts. Further purification suggests it may be a peptide present in minute amounts, requiring advanced methods for structural determination.

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    Area of Science:

    • Endocrinology
    • Neurobiology
    • Biochemistry

    Background:

    • Pineal extracts contain antigonadotropic activities beyond melatonin.
    • The precise nature and significance of these non-melatonin substances remain unclear.
    • Known pineal substances include vasotocin and releasing factors, but unidentified compounds also exist.

    Purpose of the Study:

    • To investigate and characterize a non-melatonin antigonadotropin (PAG) present in pineal extracts.
    • To differentiate PAG from known antigonadotropic substances like arginine vasotocin (AVT).
    • To explore the potential peptide nature of PAG and its biological significance.

    Main Methods:

    • Extraction and partial purification of pineal glands from various species (bovine, ovine, rat, human).

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  • Ion exchange chromatography and amino acid analysis to characterize PAG.
  • Paper chromatography and high-performance liquid chromatography (HPLC) for further purification.

    • Main Results:

    • Demonstrated the presence of a non-melatonin antigonadotropin (PAG) in purified pineal extracts.
    • Confirmed that PAG is not arginine vasotocin (AVT) through biochemical analyses.
    • Purification studies indicate PAG might be a peptide present in minute quantities.

    Conclusions:

    • A novel non-melatonin antigonadotropin (PAG) exists in pineal tissue.
    • PAG's potential peptide nature necessitates advanced purification and large-scale methods for structural elucidation.
    • High-performance chromatography is a key technique for future structural studies of PAG.