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Updated: Jul 6, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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N6-methyladenosine in myeloid cells: a novel regulatory factor for inflammation-related diseases

Jin Pang1, Tong-Dong Kuang1, Xin-Yuan Yu1

  • 1Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi, China.

Journal of Physiology and Biochemistry
|December 29, 2023
PubMed

Insights

N6-methyladenosine (m6A) regulates myeloid cell functions crucial for immunity. This review explores m6A

Area of Science:

  • Epitranscriptomics
  • Immunology
  • Molecular Biology

Background:

  • N6-methyladenosine (m6A) is a prevalent mRNA modification impacting gene expression.
  • m6A levels are altered by inflammation and linked to inflammatory diseases.
  • Myeloid cells (macrophages, dendritic cells, granulocytes) are key regulators of immune responses.

Purpose of the Study:

  • To comprehensively review the role of m6A modification in myeloid cell functions.
  • To elucidate the impact of m6A-mediated myeloid cell activity on inflammation-related diseases.
  • To identify challenges and future directions in m6A research within myeloid cells.

Main Methods:

  • Literature review focusing on m6A modification in myeloid cells.
  • Analysis of m6A's role in myeloid cell production, activation, polarization, and migration.
  • Discussion of m6A's involvement in autoimmune diseases, metabolic disorders, and cancer.

Main Results:

  • m6A critically regulates myeloid cell functions, including their development and immune responses.
  • Dysregulated m6A in myeloid cells contributes to the pathogenesis of various inflammation-related diseases.
  • m6A influences myeloid cell migration and polarization, impacting disease progression.

Conclusions:

  • m6A is a significant epigenetic regulator of myeloid cell biology and inflammation.
  • Targeting m6A pathways in myeloid cells offers potential therapeutic strategies for inflammatory diseases.
  • Further research is needed to fully understand m6A's complex roles and therapeutic potential.
Keywords:
Inflammation-related diseasesMyeloid cellsN6-methyladenosine

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