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Diabetic neuropathy: A NRF2 disease?

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Nuclear factor erythroid 2-related factor 2 (NRF2) plays a key role in diseases like diabetic neuropathy (DN). This review explores NRF2

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Area of Science:

  • Molecular Biology
  • Neuroscience
  • Pathology

Background:

  • Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor regulating genes involved in redox balance, inflammation, proteostasis, autophagy, and metabolism.
  • Dysregulation of NRF2-controlled pathways contributes to various diseases, including cardiovascular, metabolic, neurodegenerative, autoimmune disorders, and cancer.
  • Diabetic neuropathy (DN), affecting half of diabetic patients, involves damage to the peripheral and autonomic nervous systems, with NRF2 emerging as a potential therapeutic target.

Purpose of the Study:

  • To provide an updated review of NRF2 regulatory pathways in oxidative stress, inflammation, and immunity.
  • To discuss the role of NRF2 modulation in the context of diabetic neuropathy.
  • To explore the potential of NRF2 as a biomarker and therapeutic target for DN.

Main Methods:

  • Literature review of recent studies on NRF2.
  • Analysis of NRF2's role in oxidative stress, inflammation, and immunity.
  • Examination of animal models used in NRF2-related research for DN.

Main Results:

  • NRF2 is a critical regulator of cellular defense mechanisms against oxidative stress and inflammation.
  • NRF2 pathway modulation shows promise in preclinical models of DN.
  • NRF2's involvement in DN pathogenesis highlights its potential as a therapeutic target.

Conclusions:

  • NRF2 is a significant factor in the pathogenesis of numerous diseases, including DN.
  • Further research into NRF2 modulation may lead to novel therapeutic strategies for DN.
  • NRF2 holds potential as a biomarker for diagnosing and monitoring DN progression.