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Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
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Outcomes of COVID-19 patients undergoing extracorporeal membrane oxygenation: A systematic review and meta-Analysis

Shouliang Jiang1, Ping Yan2, Zhongyang Ma1

  • 1Department of Pediatrics, West China Second University Hospital, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China.

Perfusion
|December 30, 2023
PubMed

Insights

This systematic review found that Coronavirus Disease 2019 patients receiving extracorporeal membrane oxygenation (ECMO) had a 66% survival probability. Key complications included renal injury (44%) and venous thrombosis (31%).

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Pulmonology

Background:

  • The Coronavirus Disease 2019 (COVID-19) pandemic necessitated advanced respiratory support strategies.
  • Extracorporeal membrane oxygenation (ECMO) emerged as a critical intervention for severe COVID-19 cases.
  • Understanding ECMO's efficacy and associated risks is vital for patient management.

Approach:

  • A systematic review and meta-analysis was performed using PICOS criteria.
  • Searched PubMed, Web of Science, and EMBASE databases for studies up to December 10, 2022.
  • Employed random-effects meta-analysis and subgroup analysis, assessing study quality with the Newcastle-Ottawa Scale.

Key Points:

  • Analyzed 19 studies involving 1494 COVID-19 patients treated with ECMO.
  • Pooled survival probability was determined to be 66.0%.
  • Identified pooled morbidities: renal injury (44.0%), venous thrombosis (31.0%), heart failure (14.0%), liver failure (13.0%), pulmonary embolism (11.0%), pneumothorax (9.0%), pulmonary hemorrhage (9.0%), intracranial hemorrhage (8.7%), intracranial thrombosis (7.0%), gastrointestinal hemorrhage (6.0%), and gastrointestinal ischemia (6.0%).

Conclusions:

  • This meta-analysis provides crucial data on survival and complication rates for COVID-19 patients on ECMO.
  • Findings aid in evaluating the role of ECMO in managing severe COVID-19.
  • Results establish a foundation for future research into ECMO therapy for COVID-19.
Abstract

Keywords:
COVID-19complicationextracorporeal membrane oxygenationoutcomesrandomized study

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