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Correlations between the Michigan Retinal Degeneration Questionnaire and visual function parameters in patients with
J S Karuntu1, X T Nguyen1, C J F Boon1,2
1Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Acta Ophthalmologica
|December 30, 2023
Summary
Visual function tests like low-luminance visual acuity (LLVA) and mean macular sensitivity correlate with quality of life in retinitis pigmentosa (RP) patients. These measures, along with low-luminance deficit (LLD), are valuable for clinical trials in RP.
Area of Science:
- Ophthalmology
- Vision Science
- Clinical Research
Background:
- Retinitis pigmentosa (RP) is a group of inherited retinal diseases causing progressive vision loss.
- Assessing vision-related quality of life (VRQoL) is crucial for evaluating treatment efficacy in RP.
- The Michigan Retinal Degeneration Questionnaire (MRDQ) is a novel tool for assessing experienced disability in RP patients.
Purpose of the Study:
- To validate key visual function parameters as measures of VRQoL in RP patients.
- To assess the correlation between best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), low-luminance deficit (LLD), mean macular sensitivity, and fixation stability with MRDQ scores.
- To determine the utility of these visual function tests as outcome measures in RP clinical trials.
Main Methods:
- A prospective cross-sectional study included 30 RP patients.
- Visual acuity (BCVA, LLVA, LLD) was measured using Early Treatment Diabetic Retinopathy Study (ETDRS) charts.
- Mesopic microperimetry assessed mean macular sensitivity and fixation stability.
- Patients completed a Dutch translation of the MRDQ, and Spearman's rank correlation was used to analyze data.
Main Results:
- BCVA showed significant correlations with MRDQ domains for central vision and color vision.
- Lower LLVA correlated with higher experienced disability in central vision and contrast sensitivity domains.
- LLD correlated significantly with MRDQ domains for scotopic and mesopic peripheral function.
- Mean macular sensitivity was strongly associated with experienced disability across most MRDQ domains.
Conclusions:
- Visual function parameters, particularly LLVA, LLD, and mean macular sensitivity, are strongly associated with most MRDQ domains.
- These findings support the use of LLVA, LLD, and mean macular sensitivity as relevant outcome measures in clinical trials for RP.
- The study validates the utility of these objective visual function tests in reflecting the subjective VRQoL of RP patients.
Keywords:
Michigan Retinal Degeneration Questionnairelow‐luminance visual acuitymicroperimetryretinitis pigmentosaMore Related Videos
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