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07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Association between polycyclic aromatic hydrocarbons and periodontitis: Results from a large population-based study
Yuxuan Wu1, Han Yang1, Weiqiu Jin2
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Journal of Clinical Periodontology
|December 30, 2023
Summary
Exposure to polycyclic aromatic hydrocarbons (PAHs), measured via urinary metabolites, is linked to periodontitis. This research highlights environmental factors in preventing gum disease.
Area of Science:
- Environmental Health
- Oral Health
- Toxicology
Background:
- Periodontitis is a prevalent oral inflammatory condition.
- Polycyclic Aromatic Hydrocarbons (PAHs) are common environmental pollutants.
- Urinary metabolites serve as biomarkers for PAH exposure.
Purpose of the Study:
- To investigate the association between urinary PAH metabolites and periodontitis.
- To analyze independent and joint effects of multiple PAH metabolites.
Main Methods:
- Utilized data from the National Health and Nutrition Examination Survey (2009-2014).
- Employed weighted binary logistic regression, Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) regression.
- Analyzed six urinary monohydroxylated metabolites of PAHs (OH-PAHs).
Main Results:
- Included 3413 participants; higher OH-PAH levels were found in the periodontitis group (p < .001).
- Positive associations observed between individual OH-PAHs and periodontitis (p < .05).
- OH-PAHs correlated with increased attachment loss, periodontal pocket depth, and tooth loss.
Conclusions:
- PAHs and their mixtures are positively associated with periodontitis.
- Findings offer insights into periodontitis prevention through managing environmental exposures.
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