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[Eosinophilic chronic obstructive pulmonary disease: A review].
1Pirogov Russian National Research Medical University.
Terapevticheskii Arkhiv
|December 30, 2023
Summary
Chronic obstructive pulmonary disease (COPD) involves airway inflammation and remodeling. Eosinophilic COPD, a distinct subtype, may benefit from targeted therapies like monoclonal antibodies, improving prognosis.
Area of Science:
- Pulmonology
- Immunology
Background:
- Chronic obstructive pulmonary disease (COPD) is a significant global health issue characterized by airflow limitation and airway remodeling.
- A subset of COPD patients (20-40%) exhibits eosinophilic airway inflammation, similar to asthma, and this phenotype is linked to more severe airway remodeling.
Conclusions:
- Eosinophilic COPD represents a specific endotype with unique pathological features.
- Biomarkers like eosinophil counts are crucial for personalized treatment strategies in COPD.
- Targeted biologic therapies show promise for managing eosinophilic COPD, warranting further clinical investigation.
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