Related Experiment Video
Updated: Jul 6, 2025
07:09
Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
11.5K
[Hemostasis disorders in patients with systemic AL-amyloidosis]
I G Rekhtina1, V A Khyshova1, N I Zozulya1
1National Medical Research Center for Hematology.
Terapevticheskii Arkhiv
|December 30, 2023
Summary
Cutaneous hemorrhagic syndrome is common in AL-amyloidosis patients, often linked to hypercoagulation and increased thrombotic risk. This finding highlights the importance of monitoring hemostasis in these patients.
Area of Science:
- Hematology
- Internal Medicine
- Oncology
Context:
- Systemic AL-amyloidosis is a plasma cell disorder characterized by amyloid deposition.
- Hemostatic abnormalities are frequently observed in AL-amyloidosis patients.
- Understanding these complications is crucial for patient management.
Purpose:
- To investigate the frequency and characteristics of hemorrhagic and thrombotic complications in AL-amyloidosis.
- To correlate these complications with laboratory hemostasis parameters.
- To identify potential pathogenetic links between bleeding, thrombosis, and organ damage.
Summary:
- 50% of AL-amyloidosis patients experienced cutaneous hemorrhagic syndrome (vascular purpura).
- 17.5% had thrombotic events, including leg vein thrombosis and ischemic stroke.
- Hypercoagulation was prevalent (56%), associated with bleeding and thrombosis risk.
Impact:
- Establishes cutaneous hemorrhagic syndrome as a key hemostasis disorder in AL-amyloidosis.
- Reveals a link between skin hemorrhages, nephrotic syndrome, and hypercoagulable states.
- Suggests hypercoagulation and bleeding risk are intertwined, impacting patient outcomes.
Related Concept Videos
01:24Disorders of Hemostasis
922
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
922
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
702
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
702
01:27Disorders of Erythrocytes
945
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
945
01:20Extrinsic and Intrinsic Pathways of Hemostasis
7.8K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.8K
01:05Introduction to Hemostasis
7.9K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
7.9K
01:24Blood Pressure Imbalances and Circulatory Shock
782
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
782