Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Vascular Resistance01:20

Vascular Resistance

4.0K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to the letter by Tang and Liu Regarding our article "Independent and Dose-Dependent Contributions of Clonal Hematopoiesis and Mosaic Loss of Y to Incident Heart Failure".

European journal of heart failure·2026
Same author

A new era of lineage tracing.

Cell research·2026
Same author

Lineage tracing from cellular heritage to disease destiny.

Nature genetics·2026
Same author

Immunomodulatory endothelial cells contribute to T cell recruitment and activation via antigen presentation on MHC II.

Cardiovascular research·2026
Same author

Independent and Dose-Dependent Contributions of Clonal Hematopoiesis and Mosaic Loss of Y to Incident Heart Failure.

European journal of heart failure·2026
Same author

Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis.

Science advances·2026

Related Experiment Video

Updated: Jul 6, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

426

SARS-CoV-2 induced vascular endothelial dysfunction: direct or indirect effects?

Kathy O Lui1, Zhangjing Ma1, Stefanie Dimmeler2

  • 1Department of Chemical Pathology, and Li Ka Shing Institute of Health Science, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Sha Tin, New Territories, 999077 Hong Kong, China.

Cardiovascular Research
|December 30, 2023
PubMed
Summary

COVID-19 and long-COVID patients show endothelial dysfunction, but the cause—direct infection or inflammation—is debated. This review explores ACE2 expression and alternative mechanisms in SARS-CoV-2-induced vascular issues.

Keywords:
ACE2COVID-19Endothelial cellHeartSARS-CoV-2Vasculature

More Related Videos

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
00:06

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

15.3K
Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.4K

Related Experiment Videos

Last Updated: Jul 6, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

426
Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
00:06

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

15.3K
Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.4K

Area of Science:

  • Cardiovascular Biology
  • Infectious Diseases
  • Cell Biology

Background:

  • Endothelial dysfunction is prevalent in COVID-19 and long-COVID.
  • The role of direct SARS-CoV-2 infection versus systemic inflammation in endothelial damage is unclear.
  • SARS-CoV-2 entry receptor ACE2 expression varies across vascular cells.

Conclusions:

  • Understanding SARS-CoV-2's impact on the endothelium requires considering both ACE2-dependent and independent pathways.
  • Targeting vascular dysfunction mechanisms may improve treatments for cardiovascular complications of COVID-19.