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Effects of verapamil on left ventricular diastolic function at rest and during isometric exercise in patients with

M Bryhn, J Eskilsson

    Clinical Cardiology
    |January 1, 1987
    PubMed

    Insights

    Verapamil improves left ventricular diastolic function in hypertrophic cardiomyopathy patients at rest. The drug enhanced myocardial relaxation and filling, though effects diminished over time and were absent during exercise.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Hypertrophic cardiomyopathy (HCM) affects left ventricular diastolic function.
    • Verapamil is a calcium channel blocker used in cardiovascular conditions.

    Purpose of the Study:

    • To evaluate the short-term and long-term effects of verapamil on left ventricular diastolic function in HCM patients.
    • To assess verapamil's impact on myocardial relaxation and left ventricular filling.

    Main Methods:

    • Echocardiography was used to examine ten HCM patients before and during verapamil treatment.
    • Diastolic parameters were measured at rest and during isometric exercise, at baseline, 2 weeks, and 4 months of treatment.

    Main Results:

    • Verapamil significantly decreased myocardial relaxation time at rest.
    • A small, statistically significant increase in peak rate of dimension change (filling parameter) was observed at long-term follow-up.
    • No significant changes in diastolic parameters were noted during isometric exercise.

    Conclusions:

    • Verapamil demonstrates a positive effect on myocardial relaxation and left ventricular filling in HCM patients.
    • These beneficial effects are primarily observed under resting conditions and may diminish over time.

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